Title
Surrogates of protection in repeated low- dose challenge experiments
Document Type
Article
Publication Date
5-10-2015
Abstract
A critical step toward developing a successful vaccine to control the human immunodeficiency virus (HIV) pandemic entails evaluation of vaccine candidates in non-human primates (NHPs). Historically, these studies have usually entailed challenges (i.e., exposures) with very high doses of a simian version of HIV, resulting in infection of all NHPs in the experiment after a single challenge. More recently, researchers have begun to conduct repeated low-dose challenge (RLC) studies in NHPs that are believed to more closely mimic typical exposure in natural human transmission settings. One objective of RLC studies is to assess whether measured immune responses to vaccination can serve as surrogate endpoints for the primary endpoint of interest, namely infection. In this paper, different designs of RLC studies for assessing a binary surrogate of protection are considered.
Digital Commons Citation
Long, D M.; Hudgens, M G.; and Wu, C D., "Surrogates of protection in repeated low- dose challenge experiments" (2015). Clinical and Translational Science Institute. 146.
https://researchrepository.wvu.edu/ctsi/146