A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders
Metal-ion misregulation and oxidative stress have been linked to the progressive neurological decline associated with multiple neurodegenerative disorders. Transition metal-mediated oxidation of biomolecules via Fenton chemical reactions plays a role in disease progression. Herein we report the synthesis, characterization and antioxidant activity of 2; a pyclen derivative with enhanced antioxidant character.
Digital Commons Citation
Lincoln, K M.; Gonzalez, P; Richardson, T E.; and Julovich, D A., "A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders" (2013). Clinical and Translational Science Institute. 166.