New class of 8-aryl-7- deazaguanine cell permeable fluorescent probes
A one step synthesis of fluorescent 8-aryl-(7-deazaguanines) has been accomplished. Probes exhibit blue to green high quantum yield fluorescence in a variety of organic and aqueous solutions, high extinction coefficients, and large Stokes shifts often above 100 nm. The probes are highly cell permeable, and exhibit stable bright fluorescence once intracellular; therefore are suited to the design of biosensors.
Digital Commons Citation
Dhimitruka, I; Eubank, T D.; Gross, A C.; and Khramtsov, V V., "New class of 8-aryl-7- deazaguanine cell permeable fluorescent probes" (2015). Clinical and Translational Science Institute. 253.