Impacts of prenatal nanomaterial exposure on male adult Sprague-Dawley rat behavior and cognition
It is generally accepted that gestational xenobiotic exposures result in systemic consequences in the adult F1 generation. However, data on detailed behavioral and cognitive consequences remain limited. Using our whole body nanoparticle inhalation facility, pregnant Sprague Dawley rats (gestational day 7) were exposed 4 days per week to either filtered air (control) or nanotitanium dioxide aerosols (nano-TiO2; count median aerodynamic diameter of 170.9±6.4 nm, 10.4±0.4 mg/m3, 5 hr/day) for 7.8±0.5 days of the remaining gestational period. All rats received their final exposure on GD 20 prior to delivery. The calculated daily maternal deposition was 13.9±0.5 μg. Subsequently, at 5 months of age, behavior and cognitive functions of these pups were evaluated employing a standard battery of locomotion, learning, and anxiety tests. These assessments revealed significant working impairments, especially under maximal mnemonic challenge, and possible deficits in initial motivation in male F1 adults. Evidence indicates that maternal engineered nanomaterial exposure during gestation produces psychological deficits that persist into adulthood in male rats.
Digital Commons Citation
Engler-Chiurazzi, E B.; Stapleton, P A.; Stalnaker, J J.; and Ren, X, "Impacts of prenatal nanomaterial exposure on male adult Sprague-Dawley rat behavior and cognition" (1905). Clinical and Translational Science Institute. 409.