School of Medicine
Superoxide radical is involved in numerous physiological and pathophysiological processes. Tetrathiatriarylmethyl (TAM) radicals are knows to react with superoxide allowing measurement of superoxide production in biological media. We report the synthesis of a Nitro conjugated TAM radical showing a rate constant of 7 × 105 M−1s−1 which is two order of magnitude higher than other TAMs allowing high sensitivity measurement of superoxide
Digital Commons Citation
Driesschaert, Benoit; Bobko, Andrey A.; Khramtsov, Valery V.; and Zweier, Jay L., "Nitro-Triarylmethyl Radical as Dual Oxygen and Superoxide Probe" (2017). Clinical and Translational Science Institute. 496.
Driesschaert B, Bobko AA, Khramtsov VV, Zweier JL. Nitro-Triarylmethyl Radical as Dual Oxygen and Superoxide Probe. Cell Biochemistry and Biophysics. 2016;75(2):241-246. doi:10.1007/s12013-016-0732-y