School of Medicine
We present the hypothesis that an accumulation of dysfunctional mitochondria initiates a signaling cascade leading to motor neuron and muscle fiber death and culminating in sarcopenia. Interactions between neural and muscle cells that contain dysfunctional mitochondria exacerbate sarcopenia. Preventing sarcopenia will require identifying mitochondrial sources of dysfunction that are reversible.
Digital Commons Citation
Alway, Stephen E.; Mohamed, Junaith S.; and Myers, Matthew J., "Mitochondria Initiate and Regulate Sarcopenia" (2017). Clinical and Translational Science Institute. 539.
Alway SE, Mohamed JS, Myers MJ. Mitochondria Initiate and Regulate Sarcopenia. Exercise and Sport Sciences Reviews. 2017;45(2):58-69. doi:10.1249/jes.0000000000000101