Diastereoselective Base-Catalyzed Formal [4 + 2] Cycloadditions of N- Sulfonyl Imines and Cyclic Anhydrides
A diastereoselective base-catalyzed Mannich reaction of cyclic, enolizable anhydrides and Nsulfonyl imines for the synthesis of δ-lactams is reported. This anhydride Mannich reaction tolerates imines derived from aryl and enolizable aldehydes. A base-catalyzed product epimerization pathway ensures high anti diastereoselectivity in aryl and achiral enolizable imines
Digital Commons Citation
Laws, S W.; Moore, L C.; Di, M; and Nguyen, Q NN, "Diastereoselective Base-Catalyzed Formal [4 + 2] Cycloadditions of N- Sulfonyl Imines and Cyclic Anhydrides" (2017). Clinical and Translational Science Institute. 674.