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School of Pharmacy


Pharmaceutical Systems and Policy


Objective. Tis study estimated the excess clinical, humanistic, and economic burden associated with depression among workingage adults with Rheumatoid Arthritis (RA). Methods. A retrospective cross-sectional study was conducted among working-age (18 to 64 years) RA patients with depression (� = 647) and without depression (�=2,015) using data from the nationally representative Medical Expenditure Panel Survey for the years 2009, 2011, 2013, and 2015. Results. Overall, 25.8% had depression. In adjusted analyses, adults with RA and depression compared to those without depression were signifcantly more likely to have pain interference with normal work (severe pain: AOR = 2.22; 95% CI = 1.55, 3.18), functional limitations (AOR = 2.17; 95% CI = 1.61, 2.94), and lower mental health HRQoL scores. Adults with RA and depression had signifcantly higher annual healthcare expenditures ($14,752 versus 10,541, � < .001) and out-of-pocket spending burden. Adults with RA and depression were more likely to be unemployed and among employed adults, those with depression had a signifcantly higher number of missed work days annually and higher lost annual wages due to missed work days. Conclusions. Tis study highlights the importance of efectively managing depression in routine clinical practice of RA patients to reduce pain and functional limitations, improve quality of life, and lower direct and indirect healthcare costs.

Source Citation

Deb A, Dwibedi N, LeMasters T, Hornsby JA, Wei W, Sambamoorthi U. Burden of Depression among Working-Age Adults with Rheumatoid Arthritis. Arthritis. 2018;2018:1-11. doi:10.1155/2018/8463632