Date of Graduation
School of Dentistry
C. Russell Jackson.
The purpose of this study was to determine if prophylactic oral administration of etodolac would significantly reduce post-endodontic pain, when compared to ibuprofen and a placebo.;Thirty-six patients requiring conventional root canal therapy consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, prior to conventional root canal therapy. Pain evaluation was completed on a pain survey that consisted of visual analog scales at the following time intervals; initial, immediately after, 4 hours, 8 hours, 12 hours, 24 hours, 48 hours, and 72 hours after initiation of root canal therapy.;A significant difference was found for ibuprofen's ability to reduce post-endodontic pain at 4 and 8 hours after initiation of root canal therapy, when compared to etodolac and a placebo (4 Hours P-value = 0.0111; 8 Hours P-value = 0.0397). A significant difference was also found for the periapical diagnosis and the need for additional medication after completion of root canal therapy (P-value = 0.0077).
Menke, Eric Richard, "The effectiveness of prophylactic etodolac on post-endodontic pain" (1999). Graduate Theses, Dissertations, and Problem Reports. 1060.