Semester
Fall
Date of Graduation
2000
Document Type
Thesis
Degree Type
MS
College
Davis College of Agriculture, Natural Resources and Design
Department
Animal and Nutritional Sciences
Committee Chair
E. Keith Inskeep.
Abstract
Experiments were performed to determine if a short-lived corpus luteum was embryotoxic in ewes given supplemental progesterone and the route of transfer of embryotoxic products. Mated ewes were lutectomized or sham lutectomized on day 4 after estrus. Following surgery, ewes received saline or PGF 2alpha through days 6 or 7. Pregnancy rate was reduced after treatment with PGF2alpha (P < 0.001) compared to controls and was increased in PGF2alpha-treated ewes by lutectomy (P < 0.05). Mated ewes with bilateral ovulations were unilaterally lutectomized, and each uterine horn was ligated to eliminate intercornual flow on day 4 after estrus. Treatment with PGF2alpha on day 5 through 8 reduced pregnancy rates (P < 0.01), but embryonic survival did not differ in the uterine horns ipsilateral or contralateral to the regressing CL. The regressing CL is embryotoxic in progesterone-supplemented ewes, and embryotoxic luteal products have been shown to act by non-local pathways.
Recommended Citation
Costine, Beth Alyson, "Evidence for a systemic embryotoxic effect of early luteal regression in the ewe" (2000). Graduate Theses, Dissertations, and Problem Reports. 1124.
https://researchrepository.wvu.edu/etd/1124