Title

Novel synthesis of 3,4-fused indoles

Semester

Fall

Date of Graduation

2001

Document Type

Thesis

Degree Type

MS

College

Eberly College of Arts and Sciences

Department

Chemistry

Committee Chair

Bjorn C. G. Soderberg.

Abstract

The goal of this project was to synthesize 3,4-fused indoles having a variety of ring sizes and a variety of functional groups. This has been accomplished by the development of a novel palladium-catalyzed route to 3,4-fused indoles. The key steps are two palladium-catalyzed reactions, an intramolecular Heck reaction followed by a reductive N-heteroannulation. Using this route, a number of 3,4-fused indoles were prepared in acceptable yields.

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