Date of Graduation
School of Medicine
Physiology, Pharmacology & Neuroscience
Janine D. Mendola.
Amblyopia is a common developmental visual disorder. Previous studies of amblyopia have delineated spatial and binocular deficits. However debate exists about how the strabismic and anisometropic subtypes may differ. The central hypothesis is that the two subtypes differ with regard to binocular integration functions. Strabismic subjects may show severe impairments of binocular integration due to a history inter-ocular suppression, which predicts the pattern of monocular deficits. Seven anisometropic, six strabismic and seven control subjects were tested psychophysically with four monocular tests and three binocular tests. Results indicated that the degree of loss of Vernier acuity was larger than that predicted from grating acuity in strabismics but was predictable in anisometropics. Amblyopes demonstrated significant loss in binocularity, and loss in binocularity predicted loss in Vernier acuity. The results help to explain the mechanisms of vision loss and suggest that extrastriate visual cortex may be an important site of abnormality in amblyopia.
Agrawal, Ritwick, "Psychophysical studies of binocular and spatial vision in humans with anisometropic and strabismic amblyopia" (2004). Graduate Theses, Dissertations, and Problem Reports. 2002.