Date of Graduation


Document Type


Degree Type



School of Medicine


Microbiology, Immunology, and Cell Biology

Committee Chair

Susan Lemieux

Committee Co-Chair

L. A. Hornak


Noninvasive functional magnetic resonance imaging (fMRI) methods may provide new ways to detect and track renal hemodynamic changes in-vivo. In this thesis, two fMRI methods were correlated with simultaneous invasive hemodynamic measurements. A particular goal of this thesis was to measure the relative contributions of oxygenation and perfusion changes to changes in the relaxation rate, T2*. Also, an MRI compatible motion detector was built and along with the invasive probes was interfaced to a data acquisition system for use during scanning. Drug-induced changes in renal oxygenation and blood flow were measured by BOLD- & ASL-MRI noninvasively, while a dual oxygenation/perfusion optical-probe was used for the invasive measurements. Six sets of results were obtained. Values of T2*, LDF and pO2 correlated in four of the data sets while the other two were discrepant. BOLD images were of high quality while ASL perfusion maps were of inadequate spatial resolution and poor quality.