Date of Graduation
School of Pharmacy
Paula J Stout
In our research, the quality of a number of calcium supplements was evaluated by their physical properties, disintegration and dissolution profiles. Physical tests and disintegration did show a pH sensitivity. Disintegration confirmed the good uniformity of the products. In the USP required dissolution test, most of the products did not achieve acceptable drug release in the specified time period. While formulation factors and the salt form of calcium supplements can to some extent affect their dissolution pattern, it was ultimately considered that the failure may be related to the poor solubility of the calcium salts.;Based on the results and the proposed mechanisms in the failure in dissolution, a number of revised dissolution test methodologies were performed differing from the USP in attempts to increase the active ingredient's solubility and improve the dissolution test's sensitivity. A revised testing criterion was obtained by changing the parameters of agitation, dissolution volume, and dissolution medium. (Abstract shortened by UMI.).
Liu, Jianqing, "Pharmaceutical performance testing of commercially available calcium supplements" (2005). Graduate Theses, Dissertations, and Problem Reports. 4168.