Date of Graduation
Eberly College of Arts and Sciences
Aaron T Timperman
We have developed a nanofluidic microfluidic analyte concentrator for application to proteomic samples. This dissertation includes a study investigating the current rectification behavior of the device including a temporal characterization of the ON state to OFF state transition and the OFF state to ON state transition as a function of device design. An analyte concentrator compatible with proteomic samples is presented and the current rectifying phenomenon is utilized to ensure adequate analyte delivery for the enrichment process. Finally, characterization of a coating technique to alter the surface charge of the nanofluidic element from anionic to cationic is presented.
Reschke, Kathleen C., "Development of nanofluidic/microfluidic interfaces as analyte concentrators for proteomic samples" (2010). Graduate Theses, Dissertations, and Problem Reports. 4646.