Date of Graduation
College of Physical Activity and Sport Sciences
I Mark Olfert
Angiogenesis is an important adaptation to exercise, occurring in response to a multitude of different stimuli including: shear stress, mechanical stretch, ischemia, electrical stimulation, and exercise. Current thinking suggests skeletal muscle angiogenesis is a temporal process controlled by a balance between positive and negative angiogenic proteins. But there is limited information on what molecular mediators control skeletal muscle angiogenesis in this time line, creating a critical need to clarify how individual protein responses regulate physiologic skeletal muscle angiogenesis in response to exercise training and/or physical deconditioning. Our objective is to characterize the temporal expression of several key positive (VEGF, MMP-2, MMP-9, nucleolin) and negative (TSP-1, endostatin) angiogenic factors under basal conditions, after acute exercise, in response to training, and after detraining. The central hypothesis is that training and deconditioning will cause temporally coordinated changes in positive and negative angiogenic regulators in response to exercise training, which will be reversed during detraining.
Olenich, Sara A., "Temporal Expression of Key Angioregulatory Proteins in Response to Exercise and Detraining" (2013). Graduate Theses, Dissertations, and Problem Reports. 4986.