Date of Graduation
This study was undertaken to investigate the phenomenon of subsesitivity which occurs after repeated administration of an organophosphorus cholinesterase inhibitor. This manuscript has provided evidence to suggest that subsensitivity is not the result of qualitative changes in the cholinergic receptor or changes in the nerve endings. The author has suggested that a change in the number of receptors might be responsible for subsensitivity which is produced by chronic cholinesterase inhibition.
COREY, SHARON EVA, "CHANGES IN THE SENSITIVITY OF THE RAT HEART TO DRUGS AFTER CHRONIC CHOLINESTERASE INHIBITION." (1970). Graduate Theses, Dissertations, and Problem Reports. 8670.