Date of Graduation
This study was undertaken to furthur define the characteristics o f subsensitivity produced by chronic administration of cholinesterase inhibitors and to attempt to elucidate a possible mechanism by which it occurs. Administration of disulfoton, echothiophate , parathion and OMPA to rats for eight days resulted in a decreased sensitivity of segments of ileum to carbachol and a marked inhibition o f both true and total cholinesterase. The results indicate that a relationship between the degree of subsensitivity and the extent of cholinesterase inhibition may exist.
Foley, Dennis Joseph, "A Comparison Of The Effects Of Acute And Subacute Inhibition Of Cholinesterase On The Sensitivity Of Rat Tissues To Drugs" (1972). Graduate Theses, Dissertations, and Problem Reports. 8859.