Date of Graduation

1972

Document Type

Dissertation/Thesis

Abstract

This study was u n d e r t a k e n to furthur define the ch aracteristics o f s u b s e n sitivity p r o d u c e d b y chronic a dmi n i s t r a t i o n of cholinesterase inhibitors and to attempt to elucidate a pos s i b l e m e c h a n i s m b y w h i c h it occurs. A d m i n i s t r a t i o n of disulfoton, e c h o t h i o p h a t e , p a r a t h i o n and O M P A to rats for eight days r e s u l t e d in a dec r e a s e d s ensitivity of segments of il e u m to carbachol and a m a r k e d i nhibition o f bo t h true and total c holinesterase. The results indicate that a r e l a tionship b e ­ tween the degree of s u b s ensitivity an d the e x t e n t of c holinesterase inhibi t i o n ma y exist.

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