Date of Graduation
Genetic regions that are consistently altered in cancers of both mice and humans indicate regions of the genome that are good candidates for harboring genes that are critical in the development of cancer. Nearly identical breakpoints were identified at 10q21.3 in human melanoma and at the homologous 10B5.1 region in mouse lung adenocarcinoma. A previously hypothetical gene was located within the minimal breakpoint region. The gene was characterized and identified as an immediate early gene with increased expression in several of the tumor cell lines.
Senft, Jamie Riemann, "Characterization of a conserved chromosome breakpoint at 10q21.3 in human and 10B5.1 in mouse: Possible role in cancer." (2004). Graduate Theses, Dissertations, and Problem Reports. 9738.