School of Public Health
Occupational & Environmental Health Sciences
The unique physicochemical properties of multi-walled carbon nanotubes (MWCNT) have led to many industrial applications. Due to their low density and small size, MWCNT are easily aerosolized in the workplace making respiratory exposures likely in workers. The International Agency for Research on Cancer designated the pristine Mitsui-7 MWCNT (MWCNT-7) as a Group 2B carcinogen, but there was insufficient data to classify all other MWCNT. Previously, MWCNT exposed to high temperature (MWCNT-HT) or synthesized with nitrogen (MWCNT-ND) have been found to elicit attenuated toxicity; however, their genotoxic and carcinogenic potential are not known. Our aim was to measure the genotoxicity of MWCNT-7 compared to these two physicochemically-altered MWCNTs in human lung epithelial cells (BEAS-2B & SAEC).
Digital Commons Citation
Siegrist, Katelyn J.; Reynolds, Steven H.; Porter, Dale W.; Mercer, Robert R.; Bauer, Allison K.; Lowry, David; Cena, Lorenzo; Stueckle, Todd A.; Kashon, Michael L.; Wiley, John; Salisbury, Jeffrey L.; Mastovich, John; Bunker, Kristin; Sparrow, Mark; Lupoi, Jason S.; Stefaniak, Aleksandr B.; Keane, Michael J.; Tsuruoka, Shuji; Terrones, Mauricio; McCawley, Michael; and Sargent, Linda M., "Mitsui-7,Heat-treated, and Nitrogen-doped Multi-walled Carbon Nanotubes Elicit Genotoxicity in Human Lung Epithelial Cells" (2019). Faculty & Staff Scholarship. 1585.
Siegrist, K. J., Reynolds, S. H., Porter, D. W., Mercer, R. R., Bauer, A. K., Lowry, D., … Sargent, L. M. (2019). Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells. Particle and Fibre Toxicology, 16(1). https://doi.org/10.1186/s12989-019-0318-0