Document Type
Article
Publication Date
2019
College/Unit
School of Medicine
Department/Program/Center
Biochemistry
Abstract
Tumor oxygenation (pO2), acidosis (pH) and interstitial inorganic phosphate concentration (Pi) are important parameters of the malignant behavior of cancer. A noninvasive procedure that enables visualization of these parameters may provide unique information about mechanisms of tumor pathophysiology and provide clues to new treatment targets. In this research, we present a multiparametric imaging method allowing for concurrent mapping of pH, spin probe concentration, pO2, and Pi using a single contrast agent and Overhauser-enhanced magnetic resonance imaging technique. The developed approach was applied to concurrent multifunctional imaging in phantom samples and in vivo in a mouse model of breast cancer. Tumor tissues showed higher heterogeneity of the distributions of the parameters compared with normal mammary gland and demonstrated the areas of significant acidosis, hypoxia, and elevated Pi content.
Digital Commons Citation
Gorodetskii, Artem A.; Eubank, Timothy D.; Driesschaert, Benoit; Poncelet, Martin; Ellis, Emily; Khramtsov, Valery V.; and Bobko, Andrey A., "Development of Multifunctional Overhauser-enhanced Magnetic Rresonance Imaging for Concurrent in Vivo Mapping of Tumor Interstitial Oxygenation, Acidosis and Inorganic Phosphate Concentration" (2019). Faculty & Staff Scholarship. 1839.
https://researchrepository.wvu.edu/faculty_publications/1839
Source Citation
Gorodetskii, A. A., Eubank, T. D., Driesschaert, B., Poncelet, M., Ellis, E., Khramtsov, V. V., & Bobko, A. A. (2019). Development of multifunctional Overhauser-enhanced magnetic resonance imaging for concurrent in vivo mapping of tumor interstitial oxygenation, acidosis and inorganic phosphate concentration. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-48524-3
Included in
Biochemistry, Biophysics, and Structural Biology Commons, Medicine and Health Sciences Commons
Comments
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.