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Talbert et al. developed an inducible mouse model of cachexia caused by pancreatic cancer. This model exhibits features of the human condition, including the progressive depletion of muscle and adipose tissue associated with tumor progression.

Source Citation

Talbert, E. E., Cuitiño, M. C., Ladner, K. J., Rajasekerea, P. V., Siebert, M., Shakya, R., Leone, G. W., Ostrowski, M. C., Paleo, B., Weisleder, N., Reiser, P. J., Webb, A., Timmers, C. D., Eiferman, D. S., Evans, D. C., Dillhoff, M. E., Schmidt, C. R., & Guttridge, D. C. (2019). Modeling Human Cancer-induced Cachexia. Cell Reports, 28(6), 1612–1622.e4.


Talbert et al., 2019, Cell Reports 28, 1612–1622 August 6, 2019 ª 2019 The Authors.

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