Document Type
Article
Publication Date
2018
College/Unit
School of Public Health
Department/Program/Center
Epidemiology
Abstract
Background: Anemia often complicates chronic kidney disease (CKD), leading to insufficient tissue oxygenation and hypoxic injury, the factor thought to underlie progression from CKD to renal failure. Perfluorocarbons are potent oxygen transporters used in organ preservation and synthetic blood development. Data are scarce on their relationship with kidney function, especially in diabetes where anemia and hypoxia are more prevalent. We investigated the relationship of perfluoroalkyl acids (PFAS) with kidney function and variation by diabetes and anemia status.
Methods: Data on 53,650 adults (5,210 with diabetes) were obtained from the C8 Health Project. CKD was defined as an estimated glomerular filtration rate (eGFR)/min/1.73 m2. Four PFAS were investigated: perfluorohexane sulfonate (PFHxS), perfluorooctanoic acid, perfluorooctane sulfonate, and perfluorononanoic acid.
Findings: Each PFAS was positively associated with eGFR among those with CKD or anemia; this was the strongest among those with both CKD and anemia, followed by those with CKD uncomplicated by anemia. These relationships were more pronounced among those with diabetes (all P
Interpretation: PFAS are inversely associated with kidney function in CKD and diabetes, with a stronger relation observed when anemia is present.
Digital Commons Citation
Conway, Baqiyyah N.; Badders, Ashley N.; Costacou, Tina; Arthur, John M.; and Innes, Kim E., "Perfluoroalkyl substances and kidney function in chronic kidney disease, anemia, and diabetes" (2018). Faculty & Staff Scholarship. 1931.
https://researchrepository.wvu.edu/faculty_publications/1931
Source Citation
Conway, B., Badders, A., Costacou, T., Arthur, J., & Innes, K. (2018). Perfluoroalkyl substances and kidney function in chronic kidney disease, anemia, and diabetes. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Volume 11, 707–716. https://doi.org/10.2147/dmso.s173809
Included in
Biostatistics Commons, Community Health and Preventive Medicine Commons, Epidemiology Commons, Nephrology Commons
Comments
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