A Selective Cell Population from Dermis Strengthens Bone Regeneration

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Eberly College of Arts and Sciences


Exercise Physiology


Finding appropriate seed cells for bone tissue engineering remains a significant challenge. Considering that skin is the largest organ, we hypothesized that human bone morphogenetic protein receptor type IB (BmprIB)+ dermal cells could have enhanced osteogenic capacity in the healing of critical‐sized calvarial defects in an immunodeficient mouse model. In this study, immunohistochemical staining revealed that BmprIB was expressed throughout reticular dermal cells; the positive expression rate of BmprIB was 3.5% ± 0.4% in freshly separated dermal cells, by flow cytometry. Furthermore, in vitro osteogenic capacity of BmprIB+ cells was confirmed by osteogenic‐related staining and marker gene expression compared with unsorted dermal cells. In vivo osteogenic capacity was demonstrated by implantation of human BmprIB+ cell/coral constructs in the treatment of 4‐mm diameter calvarial defects in an immunodeficient mouse model compared with implantation of unsorted cell/coral constructs and coral scaffold alone. These results indicate that the selective cell population BmprIB from human dermis is a promising osteogenic progenitor cell that can be a large‐quantity and high‐quality cell source for bone tissue engineering and regeneration. Stem Cells Translational Medicine2017;6:306–315

Source Citation

Wang, T., He, J., Zhang, Y., Shi, W., Dong, J., Pei, M., & Zhu, L. (2016). A Selective Cell Population from Dermis Strengthens Bone Regeneration. STEM CELLS Translational Medicine, 6(1), 306–315. https://doi.org/10.5966/sctm.2015-0426

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