School of Medicine
In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.
A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70 Gy (62.4-75 Gy).
At a median follow-up of 14 months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in two patients (1 tracheoesophageal fistula, 1 esophageal stricture requiring repeated dilatations). No patients developed grade 3-4 pneumonitis or cardiac complications.
IMRT and IGRT may be effective for the treatment of locally advanced esophageal cancer with acceptable complications.
Digital Commons Citation
Nguyen, Nam P.; Jang, Siyoung; Vock, Jacqueline; Vinh-Hung, Vincent; Chi, Alexander; Vos, Paul; Pugh, Judith; Vo, Richard A.; Ceizyk, Misty; Desai, Anand; Smith-Raymond, Lexie; and the International Geriatric Radiotherapy Group, "Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer" (2014). Faculty & Staff Scholarship. 2544.
Nguyen, N.P., Jang, S., Vock, J. et al. Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer. BMC Cancer 14, 265 (2014). https://doi.org/10.1186/1471-2407-14-265