Document Type
Article
Publication Date
2013
College/Unit
Eberly College of Arts and Sciences
Department/Program/Center
Physics and Astronomy
Abstract
We explore the effects of the peripheral and transmembrane antimicrobial peptides on the lipid bilayer membrane by using the coarse grained Dissipative Particle Dynamics simulations. We study peptide/lipid membrane complexes by considering peptides with various structure, hydrophobicity and peptide/lipid interaction strength. The role of lipid/water interaction is also discussed. We discuss a rich variety of membrane morphological changes induced by peptides, such as pore formation, membrane corrugation and Euler buckling.
Digital Commons Citation
Chen, Licui; Jia, Nana; Gao, Lianghui; Fang, Weihai; and Golubovic, Leonardo, "Effects of Antimicrobial Peptide Revealed by Simulations: Translocation, Pore Formation, Membrane Corrugation and Euler Buckling" (2013). Faculty & Staff Scholarship. 2608.
https://researchrepository.wvu.edu/faculty_publications/2608
Source Citation
Chen, L., Jia, N., Gao, L., Fang, W., & Golubovic, L. (2013). Effects of Antimicrobial Peptide Revealed by Simulations: Translocation, Pore Formation, Membrane Corrugation and Euler Buckling. International Journal of Molecular Sciences, 14(4), 7932–7958. https://doi.org/10.3390/ijms14047932
Comments
c 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).