Document Type
Article
Publication Date
2011
College/Unit
Eberly College of Arts and Sciences
Department/Program/Center
Statistics
Abstract
Background
This paper describes the development of a web-based tool, GenDrux, which extracts and presents (over the Internet) information related to the disease-gene-drug nexus. This information is archived from the relevant biomedical literature using automated methods. GenDrux is designed to alleviate the difficulties of manually processing the vast biomedical literature to identify disease-gene-drug relationships. GenDrux will evolve with the literature without additional algorithmic modifications.
Results
GenDrux, a pilot system, is developed in the domain of breast cancer and can be accessed at http://www.microarray.uab.edu/drug_gene.pl. GenDrux can be queried based on drug, gene and/or disease name. From over 8,000 relevant abstracts from the biomedical literature related to breast cancer, we have archived a corpus of more than 4,000 articles that depict gene expression-drug activity relationships for breast cancer and related cancers. The archiving process has been automated.
Conclusions
The successful development, implementation, and evaluation of this and similar systems when created may provide clinicians with a tool for literature management, clinical decision making, thus setting the platform for personalized therapy in the future.
Digital Commons Citation
Crasto, Chiquito; Luo, Dajie; Yu, Feliciano; Forero, Andres; and Chen, Dongquan, "GenDrux: A biomedical literature search system to identify gene expression-based drug sensitivity in breast cancer" (2011). Faculty & Staff Scholarship. 2747.
https://researchrepository.wvu.edu/faculty_publications/2747
Source Citation
Crasto, C., Luo, D., Yu, F. et al. GenDrux: A biomedical literature search system to identify gene expression-based drug sensitivity in breast cancer. BMC Med Inform Decis Mak 11, 28 (2011). https://doi.org/10.1186/1472-6947-11-28
Comments
© 2011 Crasto et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.