School of Medicine
Pathology, Anatomy and Laboratory Medicine
The majority of human telomere length studies have focused on the overall length of telomeres within a cell. In fact, very few studies have examined telomere length for individual chromosome arms. The objective of this study was to examine the relationship between chromosome arm size and the relative length of the associated telomere. Quantitative Fluorescence In Situ Hybridization (Q-FISH) was used to measure the relative telomere length of each chromosome arm in metaphases from cultured lymphocytes of 17 individuals. A statistically significant positive correlation (r = 0.6) was found between telomere length and the size of the associated chromosome arm, which was estimated based on megabase pair measurements from http://www.ncbi.nlm.nih.gov/projects/mapview/.
Digital Commons Citation
Wise, Jasen L.; Crout, Richard J.; McNeil, Daniel W.; Weyant, Robert J.; Marazita, Mary L.; and Wenger, Sharon L., "Human Telomere Length Correlates to the Size of the Associated Chromosome Arm" (2009). Faculty & Staff Scholarship. 2866.
Wise JL, Crout RJ, McNeil DW, Weyant RJ, Marazita ML, Wenger SL (2009) Human Telomere Length Correlates to the Size of the Associated Chromosome Arm. PLoS ONE 4(6): e6013. https://doi.org/10.1371/journal.pone.0006013