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Gold-catalyzed C-heteroatom (C–X) coupling reactions are evaluated without using sacrificial oxidants. Vital to the success of this methodology is the nucleophile-assisted activation of aryldiazonium salts, which could be an effective oxidant for converting Au(I) to Au(III) even without the addition of an assisting ligand or photocatalyst. By accelerating the reaction kinetics to outcompete C–C homo-coupling or diazonium dediazoniation, gold-catalyzed Sandmeyer reactions were achieved with different nucleophiles, forming C–Br, C–S and C–P bonds in high yields and selectivities.

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Haihui Peng, ., Rong Cai, ., Chang Xu, ., Hao Chen, ., & Xiaodong Shi, .(2016). Nucleophile Promoted Gold Redox Catalysis With Diazonium: C-Br, C-S And C-P Bond Formation Through Catalytic Sandmeyer Coupling. Chemical Science, 7(9), 6190-6196.



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