Theses/Dissertations from 2023
Expansion on the Use of the Novel Compound, ELP-004, Using a Mycobacterium tuberculosis Experimentation Model, Kendyl Marie Berry
Evaluation of a novel mRNA-pertussis vaccine against emerging clinical isolates of Bordetella pertussis, Graham Jeffrey Bitzer
IL-27 Negatively Impacts Immunity Developed Following BCG Administration, Shelby D. Bradford
The Development of a New Pertussis Booster Formulation via the Implementation of New Adjuvants and Utilization of Alternate Routes of Administration, Megan Ashley DeJong
Burkholderia Collagen-Like Protein 8, Bucl8, Is an Outer-Membrane Component of a Novel Efflux Pump and Immunogenic Vaccine Candidate, Megan Elizabeth Grund
Glial cell-specific contribution of PKR-like ER Kinase (PERK) in neuroinflammation and behavior, Anirudhya Lahiri
Localized delivery of GM-CSF in the regulation of breast tumor oxygen and anti-tumor immunity through macrophages, Nicole E. Mihalik
Hypoxia regulates vessel-modifying macrophages and vice versa in tumors, Kayla Jo Steinberger
Theses/Dissertations from 2022
Investigating the interplay of the immune system, skin barrier, and microbiome following dermal exposure to triclosan, Rachel Baur
Bone Marrow Stroma-induced Transcriptome Signatures of Multiple Myeloma as Modulated by JUNB, Jasleen Kaur Gandhi
Cross-kingdom interactions shape soil biogeochemistry in natural and agricultural ecosystems, Jennifer Lynne Kane
Tetramerization of STAT5 has opposing roles in governing autoimmune pathogenesis, Kelly Lynn Monaghan
Examining the pulmonary response to repeated Vishniacozyma victoriae exposure and its association with allergic airway disease, Rachael Erin Rush
Understanding vaccine-induced memory responses to develop the next generation of pertussis vaccines, Kelly L. Weaver
Utilizing the K18-hACE2 mouse model to develop protective COVID-19 vaccines, Ting Y. Wong
Theses/Dissertations from 2021
Pseudomonas aeruginosa vaccine development using dual-species whole cell and subunit vaccines, Catherine Bell Blackwood
A Role for Endothelial Tissue-Nonspecific Alkaline Phosphatase in Blood-Tissue Barrier Health and Disease, Allison L. Brichacek
Utilizing the coughing rat model of pertussis to improve vaccine efficacy, Jesse M. Hall
Janus kinase 1 drives endoplasmic reticulum stress-induced transcriptional reprogramming in astrocytes, Savannah Graham Sims
Theses/Dissertations from 2020
Understanding the host immune response against Pseudomonas aeruginosa to develop novel therapeutics and vaccines, Emel Sen Kilic
Theses/Dissertations from 2019
Development of Improved Acellular Pertussis Vaccines Through Inclusion of the RTX Antigen or Induction of Mucosal Immunity, Dylan Tyler Boehm
Adaptation Of The Streptococcal Collagen-Like Protein 1, Scl1, Of Group A Streptococcus To Recognize Fibronectin Type Iii Repeats, Dudley H. Mcnitt
Theses/Dissertations from 2017
An In Vivo Evaluation of Pulmonary Immune Response and Toxicity Following Combined Respiratory Exposure to Crystalline Silica and Diesel Particulate Matter, Breanne Yingling Farris
Implications of Primary Cilia and Associated Lysophosphatidic Acid Signaling in Glioblastoma Biology and Therapy, Yuriy V. Loskutov
Nucleus Pulposus and Mesenchymal Stem Cell Preconditioning: A Focus on Redifferentiation, Wnt Signaling, and Immunity, Tyler Thomas Pizzute
Theses/Dissertations from 2016
Streptococcal collagen-like protein 1, Scl1, modulates group a Streptococcus adhesion, biofilm formation and virulence, Beth Alexandra Bachert
The effect of polymer coatings on the pulmonary toxicity of multi-walled carbon nanotubes, Lindsey M. Bishop
The Effect of Chemotherapy on Stromal Components of the Bone Marrow, Ian Woodrow Hare
Novel Immunoregulatory Elements in a Murine Model of Epicutaneous Chemical Sensitization: A Role for Regulatory T Cells and microRNA 210, Carrie Mae Long
Development of Inducible Anti-influenza Therapies, Cynthia Marie McMillen
Complex Regulation of Protein Trafficking and Photoreceptor Cell Development by Small GTPases, Zachary C. Wright
Theses/Dissertations from 2015
The Diverse Relationship of Kruppel-Like Factors 4 and 5 in Breast Cancer, Mark K. Farrugia
Myosin II Isoforms in Breast Cancer: Role of Contractility in Matrix Organization, Cell Migration, and Endothelial Barrier Function, Bridget Ruth Hindman
Kruppel-like factor 4 (KLF4) regulates protumorigenic signaling in triple-negative breast cancer (TNBC) cells, Sriganesh B. Sharma
Regulation and Function of the Cancer Stem Cell Transcription Factors GLI1 and Kruppel-like Factor 4, Daniel B. Vanderbilt
Theses/Dissertations from 2014
Implications of NEDD9 on AURKA activity: a biomarker for sensitization and therapeutic target in solid tumors, Ryan Joseph Ice
Diet Induced Alteration of the Murine Intestinal Microbiome After Antibiotic Ablation, Adam Irvin
An Overview of Acute Myeloid Leukemia and Cancer Immunology: (i) Concepts and Therapeutic Strategies and (ii) RepSox as a Candidate Cell-Engineering Tool, Audrey Nadine Jajosky
IL-15 Signaling in Skeletal Muscle: Implications in Modulation of PGC-1alpha and Mitochondrial Biogenesis, Grant C. O'Connell
Head and Neck Cancer Invasion: Contributions of Actin Regulatory Proteins and the Microenvironment, Elyse Lindsey Walk
Conceptual Learning: Enhancing Student Understanding of Physiology, Micah J. Waltz
Theses/Dissertations from 2013
The role of focal adhesion kinase in nonmuscle cell contraction, Kimberly M. Arnold
Characterization of Immune Responses to Repeated Aspergillus fumigatus Exposures, Amanda Dawn Buskirk
Altered Hemodynamic Control in the Skeletal Muscle Microcirculation in the Metabolic Syndrome: The Emergence of a new Attractor, Joshua Thomas Butcher
The Inhibition of Splicing of Glucose-6-phosphate Dehydrogenase mRNA During Starvation by Heterogeneous Nuclear Ribonucleoprotein K, Travis Cyphert
Disulfide Bridging the Gap between Src and Cortactin: A New Paradigm in SH2 Domain-mediated Signaling, Jason VanBuren Evans
Abelson Kinase Based Regulation of Tumor Cell Invasion in HNSCC, Karen E. Hayes
Characterization of the Unique Flagellar Hook Structure of the Spirochetes Borrelia burgdorferi and Treponema denticola, Kelly Ann Heintzelman Miller
The streptococcal collagen-like protein-1 (Scl1) is a multifunctional adhesin in extracellular matrix interactions, biofilm formation, and host colonization by group A Streptococcus, Heaven A. Oliver-Kozup
Regulation of anoikis by oncogenic pathways, Sun Hee Park
Theses/Dissertations from 2012
The transcription factor grainyhead-like 2 is a novel suppressor of the epithelial to mesenchymal transition, Benjamin Cieply
Characterization of terrelysin, a potential biomarker for Aspergillus terreus, Ajay Padmaj Nayak
Theses/Dissertations from 2011
Creating Reporter Systems within Drosophila melanogaster, Ashley Elizabeth Banks
Repression of PHLPP by miR-190 Contributes to Arsenic-Induced Akt Activation and Carcinogenesis, Kevin John Beezhold
Insight into the Cellular Alterations Required for Establishing Opportunistic Pseudomonas aeruginosa Infections, Dacie R. Bridge
Contraceptive Effect of a Vaccine Targeting Leukemia Inhibitory Factor that is Vital for Implantation, Angela Rae Lemons
Tyrosine Phosphorylation linked to Cardiac Arrhythmias via HCN Pacemaker Channel, Yen-Chang Lin
A New Member of the AFAP Family, AFAP1L1, Binds to Cortactin and Localizes to Invadosomes, Brandi Nicole Snyder
Role of Nitric Oxide and Reactive Oxygen Species in Apoptotic, Inflammatory and Migratory Signaling Pathways in Cancer, Siera Jo Talbott
Role of Inhibition in Binaural Processing, Jesse M. Thompson
Theses/Dissertations from 2010
Modeling central nervous system involvement in acute lymphoblastic leukemia, Stephen Matthew Akers
The Effects of Fungal Pigments on Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectral Peak Formation, Amanda Dawn Buskirk
Reovirus as a probe to study induction of anti-viral immunity and modulation of peanut allergy, Ronald J. Fecek Jr.
Dynamic Src Tyrosine Kinase Signaling Directs Invadopodia Formation and Function in Head and Neck Cancer: Novel Insights into the Original Oncogene, Laura Catherine Kelley
Regulation of anoikis by ankyrin complexes, Sanjeev Kumar
Alterations in T cell function and activation during exposure to the herbicide 3,4 dichloropropionanilide (DCPA) and its metabolites, Tricia L. Lewis
VE-Cadherin Expression and Regulation of Sensitivity to Apoptosis in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia, Heather A. O'Leary
Chemotherapy-Induced Damage of the Bone Marrow Microenvironment, Stephanie Lynne Rellick
Theses/Dissertations from 2009
Characterization of cold shock domain proteins and SUMOylation system from Oryza sativa, Vijaya Vardhana Reddy Chaikam
Prenatal cadmium exposure dysregulates sonic hedgehog and Wnt/beta-catenin signaling in the thymus resulting in immunomodulatory effects, Miranda Leah Hanson
Post-transcriptional regulation of RpoS and HemA in Salmonella, Amy Madeline Jones
Mechanism by which dietary polyunsaturated fat regulates lipogenic gene expression, Alison Bloom Kohan
Theses/Dissertations from 2008
Non-apoptotic roles of caspase-8 and caspase-2, Brooke M. Helfer
Bioinformatic Study of gamma-Secretase and its Substrates, Fei Nan
Cellular mechanisms of effects of sphingosine 1 -phosphate on vascular endothelial barrier, Mei Xu
Theses/Dissertations from 2007
Insulin-induced endothelial cell proliferation and viability in stretched murine skin and cell culture, Carl D. Shrader Jr.
The regulation and role of hypoxia inducible factor-1 (HIF-1) in human cancer, Heath Devin Skinner
Propanil (3,4-DCPA)-induced alterations of macrophage function, Irina V. Ustyugova
DNA damage response activated by anti-cancer agent, irofulven, Timothy D. Wiltshire
Theses/Dissertations from 2006
Measuring chemotaxis in Borrelia burgdorferi the Lyme disease spirochete, Richard Gerrit Bakker
Mechanisms of environmental carcinogenesis and metal -induced cellular signaling, Jacquelyn Jo Bower
Phosphatidylinositol 3-kinase/Akt signaling pathway and angiogenesis, Zongxian Cao
Chemotherapy disrupts bone marrow stromal cell function, Suzanne Davis Clutter
Intestinal and systemic cytotoxic T lymphocyte and humoral immune responses to oral and parenteral reovirus infection, Jonathan Reid Fulton
The role of PI3K/AKT/TSC/p70S6K1 pathway in tumor growth and angiogenesis, Qiao Meng
Regulation of polymeric immunoglobulin receptor by reovirus in intestinal epithelial cells, Kasturi Pal
High frequencies of HIV-1 recombination and the evolutionary potential of a hybrid retrovirus, Terence D. Rhodes
Effects of pesticide exposure on the humoral immune response following Streptococcus pneumoniae vaccination, Keith Douglas Salazar
Theses/Dissertations from 2005
Development of improved T cell receptor beta variable gene identification technology and its application post hematopoietic stem cell transplantation, Jamie Leigh Brewer
Functional MRI of rat kidney using BOLD & ASL techniques, Rajesh K. Garugu
Stationary phase induction of RpoS in enteric bacteria, Matthew Louis Hirsch
Role of the host cell in the type III translocation of Pseudomonas aeruginosa exoenzyme S, Elizabeth A. Rucks
Periplasmic flagella of the spirochetes Borrelia burgdorferi and Brachyspira hyodysenteriae, Melanie S. Sal
Theses/Dissertations from 2004
RNA analysis as a method to determine the age of a biological sample, Stacey E. Anderson
Hematotoxicity of heptachlor, Sarah Vanessa Meads Dodson