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Theses/Dissertations from 2019

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Development of Improved Acellular Pertussis Vaccines Through Inclusion of the RTX Antigen or Induction of Mucosal Immunity, Dylan Tyler Boehm

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ADAPTATION OF THE STREPTOCOCCAL COLLAGEN-LIKE PROTEIN 1, SCL1, OF GROUP A STREPTOCOCCUS TO RECOGNIZE FIBRONECTIN TYPE III REPEATS, Dudley H. McNitt

Theses/Dissertations from 2017

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An In Vivo Evaluation of Pulmonary Immune Response and Toxicity Following Combined Respiratory Exposure to Crystalline Silica and Diesel Particulate Matter, Breanne Yingling Farris

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Implications of Primary Cilia and Associated Lysophosphatidic Acid Signaling in Glioblastoma Biology and Therapy, Yuriy V. Loskutov

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Nucleus Pulposus and Mesenchymal Stem Cell Preconditioning: A Focus on Redifferentiation, Wnt Signaling, and Immunity, Tyler Thomas Pizzute

Theses/Dissertations from 2016

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Streptococcal collagen-like protein 1, Scl1, modulates group a Streptococcus adhesion, biofilm formation and virulence, Beth Alexandra Bachert

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The effect of polymer coatings on the pulmonary toxicity of multi-walled carbon nanotubes, Lindsey M. Bishop

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The Effect of Chemotherapy on Stromal Components of the Bone Marrow, Ian Woodrow Hare

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Novel Immunoregulatory Elements in a Murine Model of Epicutaneous Chemical Sensitization: A Role for Regulatory T Cells and microRNA 210, Carrie Mae Long

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Development of Inducible Anti-influenza Therapies, Cynthia Marie McMillen

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Complex Regulation of Protein Trafficking and Photoreceptor Cell Development by Small GTPases, Zachary C. Wright

Theses/Dissertations from 2015

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The Diverse Relationship of Kruppel-Like Factors 4 and 5 in Breast Cancer, Mark K. Farrugia

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Myosin II Isoforms in Breast Cancer: Role of Contractility in Matrix Organization, Cell Migration, and Endothelial Barrier Function, Bridget Ruth Hindman

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Kruppel-like factor 4 (KLF4) regulates protumorigenic signaling in triple-negative breast cancer (TNBC) cells, Sriganesh B. Sharma

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Regulation and Function of the Cancer Stem Cell Transcription Factors GLI1 and Kruppel-like Factor 4, Daniel B. Vanderbilt

Theses/Dissertations from 2014

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Implications of NEDD9 on AURKA activity: a biomarker for sensitization and therapeutic target in solid tumors, Ryan Joseph Ice

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Diet Induced Alteration of the Murine Intestinal Microbiome After Antibiotic Ablation, Adam Irvin

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An Overview of Acute Myeloid Leukemia and Cancer Immunology: (i) Concepts and Therapeutic Strategies and (ii) RepSox as a Candidate Cell-Engineering Tool, Audrey Nadine Jajosky

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IL-15 Signaling in Skeletal Muscle: Implications in Modulation of PGC-1alpha and Mitochondrial Biogenesis, Grant C. O'Connell

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Head and Neck Cancer Invasion: Contributions of Actin Regulatory Proteins and the Microenvironment, Elyse Lindsey Walk

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Conceptual Learning: Enhancing Student Understanding of Physiology, Micah J. Waltz

Theses/Dissertations from 2013

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The role of focal adhesion kinase in nonmuscle cell contraction, Kimberly M. Arnold

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Characterization of Immune Responses to Repeated Aspergillus fumigatus Exposures, Amanda Dawn Buskirk

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Altered Hemodynamic Control in the Skeletal Muscle Microcirculation in the Metabolic Syndrome: The Emergence of a new Attractor, Joshua Thomas Butcher

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The Inhibition of Splicing of Glucose-6-phosphate Dehydrogenase mRNA During Starvation by Heterogeneous Nuclear Ribonucleoprotein K, Travis Cyphert

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Disulfide Bridging the Gap between Src and Cortactin: A New Paradigm in SH2 Domain-mediated Signaling, Jason VanBuren Evans

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Abelson Kinase Based Regulation of Tumor Cell Invasion in HNSCC, Karen E. Hayes

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Characterization of the Unique Flagellar Hook Structure of the Spirochetes Borrelia burgdorferi and Treponema denticola, Kelly Ann Heintzelman Miller

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The streptococcal collagen-like protein-1 (Scl1) is a multifunctional adhesin in extracellular matrix interactions, biofilm formation, and host colonization by group A Streptococcus, Heaven A. Oliver-Kozup

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Regulation of anoikis by oncogenic pathways, Sun Hee Park

Theses/Dissertations from 2012

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The transcription factor grainyhead-like 2 is a novel suppressor of the epithelial to mesenchymal transition, Benjamin Cieply

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Characterization of terrelysin, a potential biomarker for Aspergillus terreus, Ajay Padmaj Nayak

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Evidence of a Role for Three Neuropeptides that Mediate Steroid Negative Feedback on Gonadotropin Releasing Hormone/Luteinizing Hormone Secretion in the Ewe: Kisspeptin, Neurokinin B and Orphanin FQ, Casey C. Nestor

Theses/Dissertations from 2011

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Creating Reporter Systems within Drosophila melanogaster, Ashley Elizabeth Banks

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Repression of PHLPP by miR-190 Contributes to Arsenic-Induced Akt Activation and Carcinogenesis, Kevin John Beezhold

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Insight into the Cellular Alterations Required for Establishing Opportunistic Pseudomonas aeruginosa Infections, Dacie R. Bridge

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Subcellular distribution of apoptosis associated speck-like protein mediates inflammasome assembly: A novel mechanism in the regulation of interleukin-1beta release, Nicole B. Bryan

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Contraceptive Effect of a Vaccine Targeting Leukemia Inhibitory Factor that is Vital for Implantation, Angela Rae Lemons

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Tyrosine Phosphorylation linked to Cardiac Arrhythmias via HCN Pacemaker Channel, Yen-Chang Lin

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A New Member of the AFAP Family, AFAP1L1, Binds to Cortactin and Localizes to Invadosomes, Brandi Nicole Snyder

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Role of Nitric Oxide and Reactive Oxygen Species in Apoptotic, Inflammatory and Migratory Signaling Pathways in Cancer, Siera Jo Talbott

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Role of Inhibition in Binaural Processing, Jesse M. Thompson

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Characterization of M-cadherin's Role in Regulating Apoptosis and Myogenic Differentiation of Myoblasts by Interacting with Key Components of Canonical Wnt Signaling, Yan Wang

Theses/Dissertations from 2010

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Modeling central nervous system involvement in acute lymphoblastic leukemia, Stephen Matthew Akers

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Pathophysiology and clinical implications of lower respiratory tract infection (LRTI) with respiratory enteric orphan virus (reovirus): Background and experimental evidence, Maret E. Bernard

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The Effects of Fungal Pigments on Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectral Peak Formation, Amanda Dawn Buskirk

Reovirus as a probe to study induction of anti-viral immunity and modulation of peanut allergy, Ronald J. Fecek Jr.

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Dynamic Src Tyrosine Kinase Signaling Directs Invadopodia Formation and Function in Head and Neck Cancer: Novel Insights into the Original Oncogene, Laura Catherine Kelley

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Regulation of anoikis by ankyrin complexes, Sanjeev Kumar

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Alterations in T cell function and activation during exposure to the herbicide 3,4 dichloropropionanilide (DCPA) and its metabolites, Tricia L. Lewis

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VE-Cadherin Expression and Regulation of Sensitivity to Apoptosis in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia, Heather A. O'Leary

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Chemotherapy-Induced Damage of the Bone Marrow Microenvironment, Stephanie Lynne Rellick

Theses/Dissertations from 2009

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Characterization of cold shock domain proteins and SUMOylation system from Oryza sativa, Vijaya Vardhana Reddy Chaikam

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Prenatal cadmium exposure dysregulates sonic hedgehog and Wnt/beta-catenin signaling in the thymus resulting in immunomodulatory effects, Miranda Leah Hanson

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Post-transcriptional regulation of RpoS and HemA in Salmonella, Amy Madeline Jones

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Mechanism by which dietary polyunsaturated fat regulates lipogenic gene expression, Alison Bloom Kohan

Theses/Dissertations from 2008

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Non-apoptotic roles of caspase-8 and caspase-2, Brooke M. Helfer

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Bioinformatic Study of gamma-Secretase and its Substrates, Fei Nan

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Cellular mechanisms of effects of sphingosine 1 -phosphate on vascular endothelial barrier, Mei Xu

Theses/Dissertations from 2007

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Insulin-induced endothelial cell proliferation and viability in stretched murine skin and cell culture, Carl D. Shrader Jr.

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The regulation and role of hypoxia inducible factor-1 (HIF-1) in human cancer, Heath Devin Skinner

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Propanil (3,4-DCPA)-induced alterations of macrophage function, Irina V. Ustyugova

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DNA damage response activated by anti-cancer agent, irofulven, Timothy D. Wiltshire

Theses/Dissertations from 2006

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Measuring chemotaxis in Borrelia burgdorferi the Lyme disease spirochete, Richard Gerrit Bakker

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Mechanisms of environmental carcinogenesis and metal -induced cellular signaling, Jacquelyn Jo Bower

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Phosphatidylinositol 3-kinase/Akt signaling pathway and angiogenesis, Zongxian Cao

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Chemotherapy disrupts bone marrow stromal cell function, Suzanne Davis Clutter

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Intestinal and systemic cytotoxic T lymphocyte and humoral immune responses to oral and parenteral reovirus infection, Jonathan Reid Fulton

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The role of PI3K/AKT/TSC/p70S6K1 pathway in tumor growth and angiogenesis, Qiao Meng

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Regulation of polymeric immunoglobulin receptor by reovirus in intestinal epithelial cells, Kasturi Pal

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High frequencies of HIV-1 recombination and the evolutionary potential of a hybrid retrovirus, Terence D. Rhodes

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Effects of pesticide exposure on the humoral immune response following Streptococcus pneumoniae vaccination, Keith Douglas Salazar

Theses/Dissertations from 2005

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Development of improved T cell receptor beta variable gene identification technology and its application post hematopoietic stem cell transplantation, Jamie Leigh Brewer

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Functional MRI of rat kidney using BOLD & ASL techniques, Rajesh K. Garugu

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Stationary phase induction of RpoS in enteric bacteria, Matthew Louis Hirsch

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Role of the host cell in the type III translocation of Pseudomonas aeruginosa exoenzyme S, Elizabeth A. Rucks

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Periplasmic flagella of the spirochetes Borrelia burgdorferi and Brachyspira hyodysenteriae, Melanie S. Sal

Theses/Dissertations from 2004

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RNA analysis as a method to determine the age of a biological sample, Stacey E. Anderson

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Hematotoxicity of heptachlor, Sarah Vanessa Meads Dodson

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Critical features of antigen-specific and allospecific recognition by cytotoxic T lymphocytes, Marc A. Frankenberry

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Identification and functional characterization of cataract-specific gene expression changes reveals important pathways for human lens maintenance, aging and disease, John R. Hawse IV

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Molecular modeling and experimental determination of the structure of C8 -arylguanine modified oligonucleotides that preferentially adopt the Z -DNA conformation, Sue Ellen Heavner

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CTP synthase and transporter function in Coxiella burnetii, Jeffrey D. Miller

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Mechanisms of retroviral reverse transcription and assembly, Sara Kirsten Rasmussen

Theses/Dissertations from 2003

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AFAP-110 is a cSrc activator, Joseph Myers Baisden

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Changes in immune cell populations and the antibody response to Streptococcus pneumoniae after exposure to a mixture of herbicides, Patricia de la Rosa

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Studies on the effects of propanil on macrophage function and signaling, Laura Lynn Frost

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Genetic, metabolic, and histopathological studies of particle -associated respiratory alterations, Mohamed Mohamedy Ghanem

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Rx plays multiple roles in eye development, Vera A. Voronina

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Investigation of initiation of reverse transcription in retroviruses using vectors with two primer -binding sites, Yegor A. Voronin

Theses/Dissertations from 2002

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Determining the effects of phosphorylation on AFAP-110 function, Lidia Nikolayevna Cherezova

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Expression and regulation of c-myb in B-lymphocyte development, Candice LaShawn Damiani

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Effects of high -dose chemotherapy on the bone marrow microenvironment, Brett Matthew Hall

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Immunomodulatory roles of endotoxin and glutaraldehyde in the development of latex allergy, Michael D. Howell

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Vanadate-induced cell cycle regulation and its signal transduction pathway, Zhuo Zhang

Theses/Dissertations from 2001

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Functional domain contributions to signaling specificity between the non-receptor tyrosine kinases c -Src and c -Yes, Justin Matthew Summy

Theses/Dissertations from 2000

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Induction of myosin cross-reactive antibody and cytolytic T cell responses in mice with Streptococcus pyogenes, Cynthia Ann Cunningham

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Structural determinants of murine leukemia virus (MLV) reverse transcriptase (RT) important for fidelity and drug resistance in vivo, Elias Konstantine Halvas

Theses/Dissertations from 1999

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Regulation of the synthesis and protein stability of the alternative sigma factor RpoS in Salmonella typhimurium, Christofer Lee Cunning

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Identification of the function of the carboxy terminus of AFAP-110 in regulating AFAP-110's self-association, cell localization and the integrity of actin filaments, Yong Qian