Mountaineer Undergraduate Research Review

Document Type



Transcription factors (TFs) are a vital part of every living organism on earth, as they allow for the correct genes to be expressed while much of the genome is never used. They can fall victim to mutations or manipulations that lead to the deregulation of many genes within a cell. If specific genes are over/under-expressed, a cell may become cancerous and begin replicating into a tumor. It has been demonstrated that common TFs associated with cancer can be targeted using small molecule drugs, and a popular target of these drugs is the DNA binding site on the TF along with the actual DNA sequence that the TF binds to. Disrupting a cancerous TF's ability to associate with DNA will stop it from wreaking havoc on the organism. Most TFs are also regulated by small proteins/molecules called cofactors with their unique binding site on their respective TFs. This spot also presents a potential target for drugs as many TFs cannot function without their cofactors bound. In this review, studies on disrupting TF-DNA interactions and TF-cofactor interactions with hopes of treating cancer will be discussed.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.