School of Pharmacy
Although p53 mutations are common in solid tumors, such mutations are found at a lower frequency in hematologic malignancies. In the genetic disorder Fanconi anemia (FA), p53 has been proposed as an important pathophysiological factor for two important hematologic hallmarks of the disease: bone marrow failure and leukemogenesis. Here we show that low levels of the p53 protein enhance the capacity of leukemic stem cells from FA patients to repopulate immunodeficient mice. Furthermore, boosting p53 protein levels with the use of the small molecule Nutlin-3 reduced leukemia burden in recipient mice. These results demonstrate that the level of p53 protein plays a crucial role in FA leukemogenesis.
Digital Commons Citation
Du, Wei; Li, Xiaoli; Wilson, Andrew F.; and Pang, Qishen, "A small molecule p53 activator attenuates Fanconi anemia leukemic stem cell proliferation" (2018). Clinical and Translational Science Institute. 859.
Du W, Li X, Wilson AF, Pang Q. A small molecule p53 activator attenuates Fanconi anemia leukemic stem cell proliferation. Stem Cell Research & Therapy. 2018;9(1). doi:10.1186/s13287-018-0882-5