School of Dentistry
Background. Acute and chronic orofacial pain can significantly impact overall health and functioning. Associations between fear of pain and the experience of orofacial pain are well-documented, and environmental, behavioral, and cognitive components of fear of pain have been elucidated. Little is known, however, regarding the specific genes contributing to fear of pain. Methods. A genome-wide association study (GWAS; ) was performed to identify plausible genes that may predispose individuals to various levels of fear of pain. The total score and three subscales (fear of minor, severe, and medical/dental pain) of the Fear of Pain Questionnaire-9 (FPQ-9) were modeled in a variance components modeling framework to test for genetic association with 8.5 M genetic variants across the genome, while adjusting for sex, age, education, and income. Results. Three genetic loci were significantly associated with fear of minor pain (8q24.13, 8p21.2, and 6q26; for all) near the genes TMEM65, NEFM, NEFL, AGPAT4, and PARK2. Other suggestive loci were found for the fear of pain total score and each of the FPQ-9 subscales. Conclusions. Multiple genes were identified as possible candidates contributing to fear of pain. The findings may have implications for understanding and treating chronic orofacial pain.
Digital Commons Citation
Randall, Cameron L.; Wright, Casey D.; Chernus, Jonathan M.; McNeil, Daniel W.; Feingold, Eleanor; Crout, Richard J.; Neiswanger, Katherine; Weyant, Robert J.; Shaffer, John R.; and Marazita, Mary L., "A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain" (2017). Faculty & Staff Scholarship. 1867.
Randall, C. L., Wright, C. D., Chernus, J. M., McNeil, D. W., Feingold, E., Crout, R. J., … Marazita, M. L. (2017). A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain. Pain Research and Management, 2017, 1–12. https://doi.org/10.1155/2017/7375468