Document Type

Article

Publication Date

2017

College/Unit

College of Education and Human Services

Department/Program/Center

Athletic Coaching Education

Abstract

The purpose of this investigation was to elucidate the changes in cf-DNA as it relates to fluctuations in resistance training workloads and intensities. The relationship between cell free DNA (cf-DNA), C-reactive protein (CRP), creatine kinase (CK), testosterone (T), cortisol (C), testosterone-cortisol ratio (T:C), body mass and body composition were also examined. Eight weightlifters (5 males and 3 females, age = 25 ± 3.5 yr, body mass = 88.3 ± 22.7 kg, height = 173.8 ±8.4 cm) volunteered to participate in this study. Venous blood samples, body mass and body composition were taken six times, each corresponding to the end of a training phase. CK (p = 0.018, η² = 0.409) and CK %Δ (p < 0.001, η² = 0.594) were the only biochemical variables to reach statistical significance at any point. A number of statistically significant correlations were found among variables. VLD4wk was related to CK %Δ (r = 0.86), VLD4wk %Δ was related CK %Δ (r = 0.86) and TID1wk was related to CRP (r = 0.83). cf-DNA %Δ was correlated with CRP and CRP %Δ (r = 0.83 and 0.86, respectively). CRP and CRP %Δ were correlated with BF % (r = 0.94 and 0.92, respectively). CK and CK %Δ were both related to T:C (r = 0.94 and 0.89, respectively) and T:C %Δ (r = 0.87 and 0.86, respectively). The correlation between cf-DNA and CRP suggests that cf-DNA may be a valuable indicator of inflammation in weightlifters.

Source Citation

Gentles, J. A., Hornsby, W. G., Coniglio, C. L., Dotterweich, A. R., Miller, J. A., Stuart, C. A., & Stone, M. H. (2017). Cell free DNA as a marker of training status in weightlifters. Biology of Sport, 3, 287–294. https://doi.org/10.5114/biolsport.2017.67855

Comments

Copyright: Institute of Sport. This is an Open Access article distributed under the terms of the Creative Commons Attribution Share Alike 4.0 License (https://creativecommons.org/licenses/by-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license.

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