Graphene nanoplatelets-sericin surface-modified Gum alloy for improved biological response

Authors

Valentina Mitran, University of Bucharest
Valentina Dinca, National Institute for Lasers
Raluca Ion, University of Bucharest
Vasile D. Cojocaru, University Polithenica of Bucharest
Patricia Neacsu, University of Bucharest
Cerasela Zoica Dinu, West Virginia University
Laurentiu Rusen, National Institute for Lasers
Simona Brajnicov, National Institute for Lasers & University of Craiova
Anca Bonciu, National Institute for Lasers & University of Bucharest
Maria Dinescu, National Institute for Lasers
Doina Raducanu, University of Polithenica of Bucharest
Ioan Dan, SC R&D ConsultantasiServicii SRL

Author ORCID Identifier

https://orcid.org/0000-0002-5192-9595

https://orcid.org/0000-0002-3641-5342

https://orcid.org/0000-0001-9871-4981

https://orcid.org/0000-0001-8563-2952

https://orcid.org/0000-0003-3163-034X

https://orcid.org/0000-0002-6474-6771

https://orcid.org/0000-0002-5689-8038

https://orcid.org/0000-0003-1106-8425

https://orcid.org/0000-0001-8508-0916

https://orcid.org/0000-0001-7327-8714

N/A

https://orcid.org/0000-0002-5975-4478

Document Type

Article

Publication Date

2018

College/Unit

Statler College of Engineering and Mining Resources

Department/Program/Center

Chemical and Biomedical Engineering

Abstract

In this study a “Gum Metal” titanium-based alloy, Ti-31.7Nb-6.21Zr-1.4Fe-0.16O, was synthesized by melting and characterized in order to evaluate its potential for biomedical applications. The results showed that the newly developed alloy presents a very high strength, high plasticity and a low Young's modulus relative to titanium alloys currently used in medicine. For further bone implant applications, the newly synthesized alloy was surface modified with graphene nanoplatelets (GNP), sericin (SS) and graphene nanoplatelets/sericine (GNP–SS) composite films via Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique. The characterization of each specimen was monitored by scanning electron microscopy (SEM), atomic force microscopy (AFM), contact angle (CA) measurements, and Fourier Transform Infrared Spectroscopy (FTIR). The materials' surface analyses suggested the successful coating of GNP, SS and GNP–SS onto the alloy surface. Additionally, the activities of pre-osteoblasts such as cell adhesion, cytoskeleton organization, cell proliferation and differentiation potentials exhibited on these substrates were investigated. Results showed that the GNP–SS-coated substrate significantly enhanced the growth and osteogenic differentiation of MC3T3-E1 cells when compared to bare and GNP-coated alloy. Collectively, the results show that GNP–SS surface-modified Gum alloy can modulate the bioactivity of the pre-osteoblasts holding promise for improved biological response in vivo.

Digital Commons Citation

Mitran, Valentina; Dinca, Valentina; Ion, Raluca; Cojocaru, Vasile D.; Neacsu, Patricia; Dinu, Cerasela Zoica; Rusen, Laurentiu; Brajnicov, Simona; Bonciu, Anca; Dinescu, Maria; Raducanu, Doina; and Dan, Ioan, "Graphene nanoplatelets-sericin surface-modified Gum alloy for improved biological response" (2018). Faculty & Staff Scholarship. 1991.
https://researchrepository.wvu.edu/faculty_publications/1991

Source Citation

Mitran, V., Dinca, V., Ion, R., Cojocaru, V. D., Neacsu, P., Dinu, C. Z., Rusen, L., Brajnicov, S., Bonciu, A., Dinescu, M., Raducanu, D., Dan, I., & Cimpean, A. (2018). Graphene nanoplatelets-sericin surface-modified Gum alloy for improved biological response. RSC Advances, 8(33), 18492–18501. https://doi.org/10.1039/c8ra01784k