Monika Gulia-Nuss, Purdue University
Andrew B. Nuss, Purdue University
Jason M. Meyer, Purdue University
Daniel E. Sonenshine, Old Dominion University
R. Michael Roe, North Carolina State University
Robert M. Waterhouse, University of Geneva Medical School
David B. Sattelle, University College London
Jose de la Fuente, Oklahoma State University
Jose M. Ribeiro, NIAID
Karine Megy, University of Cambridge
Jyothi Thimmapuram, Purdue University
Jason R. Miller, J. Craig Venter Institute
Brian P. Walenz, National Institutes of Health
Sergey Koren, National Institutes of Health
Jessica B. Hostetler, National Institutes of Health
Mathangi Thiagarajan, National Laboratory for Cancer Research
Vinita S. Joardar, National Institutes of Health
Linda I. Hannick, Frederick National Laboratory for Cancer Research
Shelby Bidwell, National Institutes of Health
Martin P. Hammond
Sarah Young, Broad Institute
Qiandong Zeng, Broad Institute
Jenica L. Abrudan, University of Nevada, Las Vegas
Francisca C. Almeida, Universitat de Barcelona
Ketaki Bhide, Purdue University
Brooke W. Bissinger, AgBiome, Inc.
Elena Bonzon-Kulichenko, Centro Nacional de Investigaciones Cardiovasculares
Steven D. Buckingham, University College London
Daniel R. Caffrey, University of Massachusetts Medical School
Melissa J. Caimano, University of Connecticut School of Medicine and Dentistry
Vincent Croset, University of Oxford
Timothy Driscoll, West Virginia University
Don Gilbert, Indiana University - Bloomington
Joseph J. Gillespie, University of Maryland School of Medicine
Gloria I. Giraldo-Calderon, Purdue University
Jeffrey M. Grabowski, National Institutes of Health
David Jiang, Virginia Tech
Sayed M. S. Khalil, Agricultural Genetic Engineering Research Institute
Donghun Kim, Kansas State University
Katherine M. Kocan, Oklahoma State University
Juraj Koci, University of Maryland at Baltimore
Richard J. Kuhn, Purdue University
Timothy J. Kurtti, University of Minnesota - Duluth
Kristin Lees, National University of Singapore
Emma G. Lang, Purdue University
Ryan C. Kennedy, University of California, San Francisco
Hyeogsun Kwon, Iowa State University
Rushika Perera, Colorado State University
Yumin Qi, Virginia Tech
Justin D. Radolf, University of Connecticut Health Center
Joyce M. Sakamoto, The Pennsylvania State University
Alejandro Sanchez-Gracia, Universitat de Barcelona
Maiara S. Severo, National Institutes of Health
Neal Silverman, University of Massachusetts Medical School
Marta Tojo, University of Cambridge
Cristian Tornador, Universidad Pompeu Fabra
Janice P. Van Zee, Purdue University
Jesus Vazquez, Centro Nacional de Investigaciones Cardiovasculares
Filipe G. Vieira, Universitat de Barcelona
Margarita Villar, IREC-CSIC-UCLM-JCCM
Adam R. Wespiser, University of Massachusetts Medical School
Yunlong Yang, Texas A&M University
Jiwei Zhu, North Carolina State University
Peter Arensburger, California State Polytechnic University - Pomona
Patricia V. Pietrantonio, Texas A&M University
Stephen C. Barker, University of Queensland
Renfu Shao, University of the Sunshine Coast
Evgeny M. Zdobnov, University of Geneva
Frank Hauser, University of Copenhagen
Cornelis J. P. Grimmelikhuijzen, University of Copenhagen
Yoonseong Park, Kansas State University
Julio Rozas, Universitat de Barcelona
Richard Benton, University of Lausanne
Joao H. F. Pedra, University of Maryland at Baltimore
David R. Nelson, University of Tennessee Health Science Center
Maria F. Unger, University of Notre Dame
Jose M. C. Tubio, Wellcome Trust Sanger Institute
Zhijian Tu, Virginia Tech
Hugh M. Robertson, University of Illinois at Urbana-Champaign
Martin Shumway, Max-Planck-Institut für Infektionsbiologie
Granger Sutton, J. Craig Venter Institute
Jennifer R. Wortman, Seres Therapeutics
Daniel Lawson, VectorBase/EMBL-EBI
Stephen K. Wikel, Quinnipiac University
Vishvanath M. Nene, International Livestock Research Institute
Claire M. Fraser, University of Maryland - Baltimore
Frank H. Collins, University of Notre Dame
Bruce Birren, The Broad Institute of MIT and Harvard
Karen E. Nelson, J. Craig Venter Institute
Elisabet Caler, National Institutes of Health
Catherine A. Hill, Purdue University

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Eberly College of Arts and Sciences




Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retrotransposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing B57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick–host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host ‘questing’, prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.

Source Citation

Gulia-Nuss, M., Nuss, A. B., Meyer, J. M., Sonenshine, D. E., Roe, R. M., Waterhouse, R. M., Sattelle, D. B., de la Fuente, J., Ribeiro, J. M., Megy, K., Thimmapuram, J., Miller, J. R., Walenz, B. P., Koren, S., Hostetler, J. B., Thiagarajan, M., Joardar, V. S., Hannick, L. I., Bidwell, S., … Hill, C. A. (2016). Genomic insights into the Ixodes scapularis tick vector of Lyme disease. Nature Communications, 7(1).


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