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The regional economy of the Texas High Plains (56 counties) is confronted with limited and exhaustable supplies of natural resources. This study was conducted to provide estimates of the direct labor requirements per $10,000 of production, to estimate dollar value of finished goods and services in 1980 required of each sector, and to estimate, in specific instance, the effects of irrigation water resource shortages upon labor employment opportunities. Direct, indirect and induced employment effects were derived through use of a Leontief Input-Output model. The analyses showed that final demand could increase from $5.5 billion in 1967 to $8.7 billion in 1980. In order to meet this level of production, labor employment in the region could increase from the 1967 level of 254 thousand to an estimated 406 thousand in 1980.