Semester
Summer
Date of Graduation
2022
Document Type
Thesis
Degree Type
MS
College
School of Medicine
Department
Microbiology, Immunology, and Cell Biology
Committee Chair
Michael Hu
Committee Co-Chair
Lori A Hazlehurst
Committee Member
Sijin Wen
Abstract
The bone marrow (BM) microenvironment acts as a breeding ground for drug resistance in multiple myeloma (MM). The interaction with bone marrow stromal cells (BMSCs) confer environment-mediated drug resistance (EMDR) to multiple myeloma. We investigated BM stroma-induced transcriptome signatures of MM cells through a sophisticated analysis of gene expression. In particular, we defined transcription program modulated by JunB, an emerging regulator of MM pathogenesis and a member of the transcription factor superfamily activator protein 1 (AP-1), in response to BM stimulation. The data and results lay down a foundation for future studies to illustrate the regulatory role of JunB in the de novo drug resistance of multiple myeloma.
Recommended Citation
Gandhi, Jasleen Kaur, "Bone Marrow Stroma-induced Transcriptome Signatures of Multiple Myeloma as Modulated by JUNB" (2022). Graduate Theses, Dissertations, and Problem Reports. 11358.
https://researchrepository.wvu.edu/etd/11358