Title
Loss of cytokeratin 20 and acquisition of thyroid transcription factor-1 expression in a merkel cell carcinoma metastasis to the brain
Document Type
Article
Publication Date
11-1-2014
Abstract
Merkel cell carcinoma is recognized by its morphologic features as well as by its classic immunophenotypic properties. Although Merkel cell carcinomas demonstrating non-classic immunoreactivities have been described, a case documenting a change in immunophenotype during the course of disease progression has not been previously reported. We report a case of Merkel cell carcinoma which initially demonstrated cytokeratin 20 positivity but lost expression in subsequent metastases. Likewise, thyroid transcription factor-1 was initially negative in the tumor but expression was present in metastatic lesions.
Digital Commons Citation
Shalin, S C.; Cifarelli, C P.; Suen, J Y.; and Gao, L, "Loss of cytokeratin 20 and acquisition of thyroid transcription factor-1 expression in a merkel cell carcinoma metastasis to the brain" (2014). Clinical and Translational Science Institute. 106.
https://researchrepository.wvu.edu/ctsi/106