Title

Association of periodontitis and human papillomavirus in oral rinse specimens: Results from the National Health and Nutrition Survey 2009-2012

Document Type

Article

Publication Date

6-1-2015

Abstract

Background—Human papillomavirus (HPV) positive oropharyngeal squamous cell carcinomas are increasing in incidence and are becoming significant public health concerns. Periodontitis is a chronic condition in which the affected tissue may facilitate oral HPV infection and persistence. The purpose of this study was to determine if an association of the presence of HPV in oral rinse specimens and periodontal disease exists. Methods—The National Health and Nutrition Examination Survey data for years 2009–10 and 2011–12 were combined. Participants ages 30–69 years with clinically assessed periodontal and HPV data were included in the study (n=6,004). The data were analyzed with Rao Scott Chi Square and logistic regression. Results—There were 498 participants who had the presence of HPV in oral rinse specimens. The adjusted odds ratio for the presence of HPV in oral rinse specimens with relation to periodontal disease was 1.04 (95% confidence interval: 0.63, 1.73), adjusting for sex, race/ethnicity, education, age, income to poverty ratio, smoking, alcohol use and number of lifetime sex partners. Conclusions—The researchers failed to reject the hypothesis of no association of the presence of HPV in oral rinse specimens and periodontitis. Practical Implications—Although oral HPV infection is a serious concern, periodontitis was not shown to be related to the presence of HPV in oral rinse specimens in adjusted analyses in this study.

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