"Durable Near-Complete Response to Anti-PD-1 Checkpoint Immunotherapy i" by James T. Boothe, G. Thomas Budd et al.
 

Document Type

Article

Publication Date

11-13-2017

College/Unit

School of Medicine

Abstract

Solitary fibrous tumor of the pleura is a rare and usually benign primary neoplasm arising from mesenchymal cells of the submesothelial tissue. We present here the case of a patient diagnosed with CD34-positive advanced malignant solitary fibrous tumor of the pleura whose disease failed to respond to combination cytotoxic chemotherapy agents, but demonstrated a prompt near-complete response to checkpoint blockade treatment using the anti-programmed death (PD)-1 monoclonal antibody pembrolizumab, based on tumor molecular profiling revealing tumoral expression positivity for both programmed death-ligand 1 (PD-L1) and PD-1. The patient experienced minimal adverse effects from the treatment with durable favorable response lasting up to cycle 26.

Source Citation

Boothe JT, Budd GT, Smolkin MB, Ma PC. Durable Near-Complete Response to Anti-PD-1 Checkpoint Immunotherapy in a Refractory Malignant Solitary Fibrous Tumor of the Pleura. Case Reports in Oncology. November 2017:998-1005. doi:10.1159/000484041

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