Semester
Summer
Date of Graduation
2005
Document Type
Thesis
Degree Type
MS
College
School of Dentistry
Department
Not Listed
Committee Chair
C. Russell Jackson.
Abstract
Pain is often associated with teeth that need endodontic therapy. This pain results from inflammation. Non-Steroidal Anti-Inflammatory Drugs are useful in managing acute post-operative dental pain. NSAIDS specific for only blocking the COX-2 enzyme cause less stomach irritation and bleeding. The purpose of this clinical study was to determine if pre-operative administration of valdecoxib would significantly reduce post-endodontic pain, when compared to ibuprofen. Sixteen patients were evaluated. The patients consented to a random, one-time, pre-operative oral administration of either 600 mg ibuprofen or 20 mg valdecoxib. Each patient rated their pain on a visual analog scale at initial, immediately after, 4, 8, 12, 24, 48, and 72 hours after initiation of endodontic therapy. Statistical analysis with a two factor ANOVA showed there was no significant difference (p>0.05) between valdecoxib and ibuprofen at controlling post-endodontic pain over time. In conclusion, valdecoxib and ibuprofen appear to have equal efficacy at controlling post-endodontic pain when administered pre-operatively..
Recommended Citation
Ford, Lora Beth, "The effectiveness of valdecoxib on post-endodontic pain" (2005). Graduate Theses, Dissertations, and Problem Reports. 2286.
https://researchrepository.wvu.edu/etd/2286