Semester

Spring

Date of Graduation

1999

Document Type

Thesis

Degree Type

MS

College

Statler College of Engineering and Mineral Resources

Department

Industrial and Managements Systems Engineering

Committee Chair

Warren R. Myers.

Abstract

Subjects were exposed to different concentrations of CFC-113 for variable duration while conducting 30-minute exercise regiments. End-exhaled breath samples were collected 25, 30 and 35 minutes after the exercise regiment and quantified using gas chromatography. Three comparative studies were conducted.;A short duration administration delivered at the beginning or at the end of the regiment was compared to a long duration administration delivered at the beginning or at the end of the exercise regiment. The second study compared breath samples when 500 ppm of CFC-113 was administered at the beginning or end six minutes of the regiment. The third compared continuous exposures (30 min of 100 ppm) to intermittent exposures (three intermittent 2-min exposures of 500 ppm). This study determined that equivalent doses of CFC-113 administered with variable exposure profiles to human subjects produced statistically equivalent end-exhaled CFC-113 concentration, except in two cases.

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