Date of Graduation

1967

Document Type

Dissertation/Thesis

Abstract

Comparative rates of the free radical addition of mercaptoacetic acid to substituted phenylcyclohexenes have been studied with special reference to the activities of the olefins against Lewis Lung Carcinoma, Sarcoma 180, Lymphoid Leukemia and KB Cultures. All cancer screening data were supplied by the Cancer Chemotherapy National Service Center at the National Cancer Center. The rates of addition of mercaptoacetic acid to substituted phenylcyclohexenes were determined by measuring the amount of unreacted mercaptoacetic acid by iodine titration. The reaction was studied at 1:1, 2:1, and 3:1 thlol:olefin molar ratios. At a 2:1 ratio the rates were approximately doubled and at a 3:1 ratio the rates were approximately tripled. The following order of reactivity was observed; p<-OCH.j>o-OCH3 >p-CR3 >m-OCH3 >m-CH3 >H> trimethoxy>dimethoxy>o-CH3 .

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