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The Addiction Severity Index is the most widely used intake instrument for substance abuse treatment. The National Comorbidity Study (Kessler et al. 1994) indicated that 13.7% of the United States population suffers from a concurrent substance use and mental health disorder within a lifetime. This study explored the utility of the Addiction Severity Index (ASI) and demographic factors as predictors of treatment as rated by staff at discharge. The records of 146 individuals with substance use and mental health diagnoses admitted to a freestanding residential treatment center in Northwestern Pennsylvania were examined to access the predictive properties of the ASI and demographic factors. The sample consisted of 87 males, and 59 females. A number of ASI Composite Scores and Patient Severity Ratings were significant in predicting treatment outcome as rate by staff at discharge. Demographic factors predictive of treatment outcome by staff at discharge were: time in treatment and living situation. Implications and limitations of the study are discussed and recommendations are made for future research in utilization of the ASI and demographic factors in predicting treatment outcome at intake.