Document Type
Article
Publication Date
2018
College/Unit
Statler College of Engineering and Mining Resources
Department/Program/Center
Chemical and Biomedical Engineering
Abstract
Apple pomace, which is a waste byproduct of processing, is rich in several nutrients, particularly dietary fiber, indicating potential benefits for diseases that are attributed to poor diets, such as non-alcoholic fatty liver disease (NAFLD). NAFLD affects over 25% of United States population and is increasing in children. Increasing fruit consumption can influence NAFLD. The study objective was to replace calories in standard or Western diets with apple pomace to determine the effects on genes regulating hepatic lipid metabolism and on risk of NAFLD. Female Sprague-Dawley rats were randomly assigned (n = 8 rats/group) to isocaloric diets of AIN-93G and AIN-93G/10% w/w apple pomace (AIN/AP) or isocaloric diets of Western (45% fat, 33% sucrose) and Western/10% w/w apple pomace (Western/AP) diets for eight weeks. There were no significant effects on hepatic lipid metabolism in rats fed AIN/AP. Western/AP diet containing fiber-rich apple pomace attenuated fat vacuole infiltration, elevated monounsaturated fatty acid content, and triglyceride storage in the liver due to higher circulating bile and upregulated hepatic DGAT2 gene expression induced by feeding a Western diet. The study results showed the replacement of calories in Western diet with apple pomace attenuated NAFLD risk. Therefore, apple pomace has the potential to be developed into a sustainable functional food for human consumption.
Digital Commons Citation
Skinner, Roy Chris; Warren, Derek C.; Lateef, Soofie N.; Benedito, Vagner A.; and Tou, Janet C., "Apple Pomace Consumption Favorably Alters Hepatic Lipid Metabolism in Young Female Sprague-Dawley Rats Fed a Western Diet" (2018). Faculty & Staff Scholarship. 1286.
https://researchrepository.wvu.edu/faculty_publications/1286
Source Citation
Skinner, R., Warren, D., Lateef, S., Benedito, V., & Tou, J. (2018). Apple Pomace Consumption Favorably Alters Hepatic Lipid Metabolism in Young Female Sprague-Dawley Rats Fed a Western Diet. Nutrients, 10(12), 1882. https://doi.org/10.3390/nu10121882
Included in
Animal Sciences Commons, Chemical Engineering Commons, Nutrition Commons, Plant Sciences Commons
Comments
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
This article received support from the WVU Libraries' Open Access Author Fund.