Document Type
Article
Publication Date
2018
College/Unit
School of Pharmacy
Department/Program/Center
Pharmaceutical Sciences
Abstract
Addition of nanoclays into a polymer matrix leads to nanocomposites with enhanced properties to be used in plastics for food packaging applications. Because of the plastics’ high stored energy value, such nanocomposites make good candidates for disposal via municipal solid waste plants. However, upon disposal, increased concerns related to nanocomposites’ byproducts potential toxicity arise, especially considering that such byproducts could escape disposal filters to cause inhalation hazards. Herein, we investigated the effects that byproducts of a polymer polylactic acid-based nanocomposite containing a functionalized montmorillonite nanoclay (Cloisite 30B) could pose to human lung epithelial cells, used as a model for inhalation exposure. Analysis showed that the byproducts induced toxic responses, including reductions in cellular viability, changes in cellular morphology, and cytoskeletal alterations, however only at high doses of exposure. The degree of dispersion of nanoclays in the polymer matrixappeared to influence the material characteristics, degradation, and ultimately toxicity. With toxicity of the byproduct occurring at high doses, safety protocols should be considered, along with deleterious effects investigations to thus help aid in safer, yet still effective products and disposal strategies.
Digital Commons Citation
Wagner, Alixandra; White, Andrew P.; Tang, Man Chio; Agarwal, Sushant; Stueckle, Todd A.; Rojanasakul, Yon; Gupta, Rakesh K.; and Dinu, Carasela Zoica, "Incineration of Nanoclay Composites Leads to Byproducts with Reduced Cellular Reactivity" (2018). Faculty & Staff Scholarship. 1509.
https://researchrepository.wvu.edu/faculty_publications/1509
Source Citation
Wagner, A., White, A. P., Tang, M. C., Agarwal, S., Stueckle, T. A., Rojanasakul, Y., Gupta, R. K., & Dinu, C. Z. (2018). Incineration of Nanoclay Composites Leads to Byproducts with Reduced Cellular Reactivity. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-28884-y
Included in
Biomedical Engineering and Bioengineering Commons, Chemical Engineering Commons, Pharmacy and Pharmaceutical Sciences Commons
Comments
Open Access This article is licensed under a Creative Commons Attribution 4.0 International
License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre- ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per- mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
© The Author(s) 2018