Document Type
Article
Publication Date
2019
College/Unit
School of Public Health
Department/Program/Center
Occupational & Environmental Health Sciences
Abstract
The unique physicochemical properties of multi-walled carbon nanotubes (MWCNT) have led to many industrial applications. Due to their low density and small size, MWCNT are easily aerosolized in the workplace making respiratory exposures likely in workers. The International Agency for Research on Cancer designated the pristine Mitsui-7 MWCNT (MWCNT-7) as a Group 2B carcinogen, but there was insufficient data to classify all other MWCNT. Previously, MWCNT exposed to high temperature (MWCNT-HT) or synthesized with nitrogen (MWCNT-ND) have been found to elicit attenuated toxicity; however, their genotoxic and carcinogenic potential are not known. Our aim was to measure the genotoxicity of MWCNT-7 compared to these two physicochemically-altered MWCNTs in human lung epithelial cells (BEAS-2B & SAEC).
Digital Commons Citation
Siegrist, Katelyn J.; Reynolds, Steven H.; Porter, Dale W.; Mercer, Robert R.; Bauer, Allison K.; Lowry, David; Cena, Lorenzo; Stueckle, Todd A.; Kashon, Michael L.; Wiley, John; Salisbury, Jeffrey L.; Mastovich, John; Bunker, Kristin; Sparrow, Mark; Lupoi, Jason S.; Stefaniak, Aleksandr B.; Keane, Michael J.; Tsuruoka, Shuji; Terrones, Mauricio; McCawley, Michael; and Sargent, Linda M., "Mitsui-7,Heat-treated, and Nitrogen-doped Multi-walled Carbon Nanotubes Elicit Genotoxicity in Human Lung Epithelial Cells" (2019). Faculty & Staff Scholarship. 1585.
https://researchrepository.wvu.edu/faculty_publications/1585
Source Citation
Siegrist, K. J., Reynolds, S. H., Porter, D. W., Mercer, R. R., Bauer, A. K., Lowry, D., … Sargent, L. M. (2019). Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells. Particle and Fibre Toxicology, 16(1). https://doi.org/10.1186/s12989-019-0318-0
Comments
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.