Document Type
Article
Publication Date
2018
College/Unit
School of Medicine
Department/Program/Center
Pediatrics
Abstract
Although p53 mutations are common in solid tumors, such mutations are found at a lower frequency in hematologic malignancies. In the genetic disorder Fanconi anemia (FA), p53 has been proposed as an important pathophysiological factor for two important hematologic hallmarks of the disease: bone marrow failure and leukemogenesis. Here we show that low levels of the p53 protein enhance the capacity of leukemic stem cells from FA patients to repopulate immunodeficient mice. Furthermore, boosting p53 protein levels with the use of the small molecule Nutlin-3 reduced leukemia burden in recipient mice. These results demonstrate that the level of p53 protein plays a crucial role in FA leukemogenesis.
Digital Commons Citation
Du, Wei; Li, Xiaoli; Wilson, Andrew F.; and Pang, Qishen, "A small molecule p53 activator attenuates Fanconi anemia leukemic stem cell proliferation" (2018). Faculty & Staff Scholarship. 1627.
https://researchrepository.wvu.edu/faculty_publications/1627
Source Citation
Du, W., Li, X., Wilson, A. F., & Pang, Q. (2018). A small molecule p53 activator attenuates Fanconi anemia leukemic stem cell proliferation. Stem Cell Research & Therapy, 9(1). https://doi.org/10.1186/s13287-018-0882-5
Comments
© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.