Author ORCID Identifier
https://orcid.org/0000-0003-0824-0773
https://orcid.org/0000-0003-1897-1131
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https://orcid.org/0000-0002-0766-8455
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https://orcid.org/0000-0003-3392-6881
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Document Type
Article
Publication Date
2017
College/Unit
School of Dentistry
Department/Program/Center
Dental Practice & Rural Health
Abstract
Matrix metalloproteinases (MMPs), which degrade extracellular proteins as part of a variety of physiological processes, and their inhibitors have been implicated in the dental caries process. Here we investigated 28 genetic variants spanning the MMP10, MMP14, and MMP16 genes to detect association with dental caries experience in 13 age- and race-stratified () samples from 6 parent studies. Analyses were performed separately for each sample, and results were combined across samples by meta-analysis. Two SNPs (rs2046315 and rs10429371) upstream of MMP16 were significantly associated with caries in an individual sample of white adults and via meta-analysis across 8 adult samples after gene-wise adjustment for multiple comparisons. Noteworthy is SNP rs2046315 () association with caries in white adults. This SNP was originally nominated in a genome-wide-association study (GWAS) of dental caries in a sample of white adults and yielded associations in a subsequent GWAS of surface level caries in white adults as well. Therefore, in our study, we were able to recapture the association between rs2046315 and dental caries in white adults. Although we did not strengthen evidence that MMPs 10, 14, and 16 influence caries risk, MMP16 is still a likely candidate gene to pursue.
Digital Commons Citation
Lewis, D D.; Shaffer, J R.; Feingold, E; Cooper, M; Vanyukov, M M.; Maher, B S.; Slayton, R L.; Willing, M C.; Reis, S E.; Mcneil, D W.; Weyant, R J.; Vieira, A R.; and Marazita, M L., "Genetic Association of MMP10, MMP14, and MMP16 with Dental Caries" (2017). Faculty & Staff Scholarship. 1871.
https://researchrepository.wvu.edu/faculty_publications/1871
Source Citation
Lewis, D. D., Shaffer, J. R., Feingold, E., Cooper, M., Vanyukov, M. M., Maher, B. S., … Marazita, M. L. (2017). Genetic Association ofMMP10,MMP14, andMMP16with Dental Caries. International Journal of Dentistry, 2017, 1–7. https://doi.org/10.1155/2017/8465125
Comments
Copyright © 2017 D. D. Lewis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.